RESIDUAL EFFECT OF WATER-SOLUBLE C60 FULLERENE ON THE MUSCLE SOLEUS AND MUSCLE GASTROCNEMIUS CONTRACTION IN RATS WITH THE DEVELOPMENT OF FATIGUE

A comparison of biomechanical and biochemical markers muscle soleus gastrocnemius fatigue in rats for two days after 5 using antioxidant C60 fullerene (daily dose was 1 mg·kg-1) performed. It shown that its long-term use to increase strength response against the background by 60-65 35-40% slow fast muscle, respectively. The residual effect water-soluble on remains significant (20-25%) even 2 discontinuation drug. At same time, 2nd day at a minimum level, which does not significantly performance. Prolonged usage helps reduce oxidative processes 30-40% 21-25% muscles maintaining balance between prooxidants defense system. comparative analysis stress indicators state systems showed therapeutic is higher than gastrocnemius. obtained results demonstrate kinetics excretion from body, contributes (at least days) compensatory activation endogenous system stimulation, should be considered when developing new drugs based it.